PDF DatasheetHuman CD10 / Neprilysin / MME Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD10 / Neprilysin / MME based upon sequence from: Human
Host: QP9276 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD10 / Neprilysin / MME, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9276.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Tyr52 – Trp750
Amino Acid Sequence: YDDGICKSSD CIKSAARLIQ NMDATTEPCT DFFKYACGGW LKRNVIPETS SRYGNFDILR DELEVVLKDV LQEPKTEDIV AVQKAKALYR SCINESAIDS RGGEPLLKLL PDIYGWPVAT ENWEQKYGAS WTAEKAIAQL NSKYGKKVLI NLFVGTDDKN SVNHVIHIDQ PRLGLPSRDY YECTGIYKEA CTAYVDFMIS VARLIRQEER LPIDENQLAL EMNKVMELEK EIANATAKPE DRNDPMLLYN KMTLAQIQNN FSLEINGKPF SWLNFTNEIM STVNISITNE EDVVVYAPEY LTKLKPILTK YSARDLQNLM SWRFIMDLVS SLSRTYKESR NAFRKALYGT TSETATWRRC ANYVNGNMEN AVGRLYVEAA FAGESKHVVE DLIAQIREVF IQTLDDLTWM DAETKKRAEE KALAIKERIG YPDDIVSNDN KLNNEYLELN YKEDEYFENI IQNLKFSQSK QLKKLREKVD KDEWISGAAV VNAFYSSGRN QIVFPAGILQ PPFFSAQQSN SLNYGGIGMV IGHEITHGFD DNGRNFNKDG DLVDWWTQQS ASNFKEQSQC MVYQYGNFSW DLAGGQHLNG INTLGENIAD NGGLGQAYRA YQNYIKKNGE EKLLPGLDLN HKQLFFLNFA QVWCGTYRPE YAVNSIKTDV HSPGNFRIIG TLQNSAEFSE AFHCRKNSYM NPEKKCRVW
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD10 / Neprilysin / MME Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD10 / Neprilysin / MME Protein General Information | |
|---|---|
| Alternate Names | |
| CD10; Neprilysin; MME; C85356; SFE; NEP; CD10; 6030454K05Rik; CALLA | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MME |
| Entrez Gene ID | 4311 |
| Ensemble Gene ID | ENSG00000196549 |
| RefSeq Protein Accession(s) | NP_000893.2 |
| RefSeq mRNA Accession(s) | NM_000902.3, NM_007287.2, NM_007288.2, NM_007289.2, XM_006713646.3, XM_006713647.3, XM_011512855.2, XM_011512856.2, XM_011512857.2 |
| UniProt ID(s) | P08473 |
| UniGene ID(s) | Hs.307734 |
| HGNC ID(s) | HGNC:7154 |
| COSMIC ID Link(s) | MME |
| KEGG Gene ID(s) | hsa:4311 |
| PharmGKB ID(s) | PA30864 |
| General Description of Recombinant Human CD10 / Neprilysin / MME Protein. | |
| Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids . Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 . Involved in the degradation of atrial natriuretic factor (ANF) . Displays UV-inducible elastase activity toward skin preelastic and elastic fibers . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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