PDF DatasheetHuman Anti-CD11b Antibody Product Attributes
CD11b Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD11b antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow. Low, but measureable presence of CD11b could be seen in cells in the molecular layer in cerebellum, glial cells in the caudate nucleus, cerebral cortex and hippocampus and macrophages in lung. We were unable to detect CD11b in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD11b General Information | |
|---|---|
| Alternate Names | |
| Complement Receptor 3A, CR3A, ITGAM | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ITGAM |
| Entrez Gene ID | 3684 |
| Ensemble Gene ID | ENSG00000169896 |
| RefSeq Protein Accession(s) | XP_016878705, NP_000623, XP_011544152, NP_001139280, XP_011544153, XP_006721108 |
| RefSeq mRNA Accession(s) | XM_006721045, NM_000632, XM_011545850, XM_017023216, NM_001145808, XM_011545851, XR_950796, |
| RefSeq Genomic Accession(s) | NC_000016, NG_011719, NC_018927 |
| UniProt ID(s) | P11215 |
| UniGene ID(s) | P11215 |
| HGNC ID(s) | 6149 |
| Cosmic ID(s) | ITGAM |
| KEGG Gene ID(s) | hsa:3684 |
| PharmGKB ID(s) | PA29949 |
| General Description of CD11b. | |
| The ICRF44 antibody reacts with human CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The ICRF44 antibody is widely used as a marker for CD11b expression on macrophages, granulocytes, and subsets of NK cells. It is reported to be cross-reactive with a number of non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus and Swine. | |
Selected References
Limitations and Warranty
| Size | |
|---|---|
| Tag | APC, FITC, PE, PE-Cy7, Qfluor™ 630, Unconjugated |
| Buffer and Stabilizer | 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2, 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2 |
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| Mass Spec Validated? |
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