PDF DatasheetHuman Anti-CD11c Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD11c Antibody Clone: ITGAX/1243
Clone ITGAX/1243 Host and Isotype: Mouse IgG2b kappa
Anti-Human CD11c Positive Control Sample: Human dendritic cells. Human lymph nodes and tonsils.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human ITGAX protein fragment (aa 637-827)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD11c Previously Observed Antibody Staining Patterns
| CD11c General Information | |
|---|---|
| Alternate Names | |
| CD11 antigen-like family member C, Complement component 3 receptor 4 subunit, Integrin alpha-X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), Leu M5 alpha subunit, Leukocyte adhesion glycoprotein p150 95 alpha chain, Myeloid membrane antigen alpha subunit, p150/95, anti-CD11 antigen-like family member C antibody, anti-Complement component 3 receptor 4 subunit antibody, anti-Integrin alpha-X antibody, anti-integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody, anti-Leu M5 alpha subunit antibody, anti-Leukocyte adhesion glycoprotein p150 95 alpha chain antibody, anti-Myeloid membrane antigen alpha subunit antibody, anti-p150/95 antibody | |
| Molecular Weight | |
| 145kDa | |
| Curated Database and Bioinformatic Data | |
| Entrez Gene ID | 3687 |
| Ensemble Gene ID | ENSG00000140678 |
| RefSeq Protein Accession(s) | XP_011544156, NP_000878, NP_001273304, XP_011544154 |
| RefSeq mRNA Accession(s) | NM_001286375, NM_000887 XR_950797, XM_011545852, XM_011545854 |
| RefSeq Genomic Accession(s) | NG_011451, NC_000016, NC_018927 |
| UniProt ID(s) | H3BN02, P20702 |
| UniGene ID(s) | H3BN02, P20702 |
| HGNC ID(s) | 6152 |
| Cosmic ID(s) | ITGAX |
| KEGG Gene ID(s) | hsa:3687 |
| PharmGKB ID(s) | PA29952 |
| General Description of CD11c. | |
| Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues. | |
Limitations and Warranty
enQuire Bio’s CD11c Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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