PDF DatasheetHuman, Cynomolgus Monkey, Rhesus Monkey, Rat (-), Sheep (-), Cow (-), and Canine (-) Anti-CD34 Antibody Product Attributes
CD34 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CD34 antibody staining is expected to be primarily localized to the cell junctions, nucleus and plasma membrane.
Observed Antibody Staining Data By Tissue Type:
Variations in CD34 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney and endothelial cells in the cerebral cortex and colon. More moderate antibody staining intensity was present in cells in the glomeruli in kidney and endothelial cells in the cerebral cortex and colon. Low, but measureable presence of CD34 could be seen in. We were unable to detect CD34 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD34 General Information | |
|---|---|
| Alternate Names | |
| Hematopoietic progenitor cell antigen CD34, CD34 antigen, CD34, Cluster of Differentiation 34 | |
| Molecular Weight | |
| 90-110kDa | |
| Chromosomal Location | |
| 1q32.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD34 |
| Entrez Gene ID | 947 |
| Ensemble Gene ID | ENSG00000174059 |
| RefSeq Protein Accession(s) | NP_001764, NP_001020280 |
| RefSeq mRNA Accession(s) | NM_001773, NM_001025109 |
| RefSeq Genomic Accession(s) | NC_018912, NC_000001 |
| UniProt ID(s) | P28906 |
| UniGene ID(s) | P28906 |
| HGNC ID(s) | 1662 |
| Cosmic ID(s) | CD34 |
| KEGG Gene ID(s) | hsa:947 |
| PharmGKB ID(s) | PA26211 |
| General Description of CD34. | |
| This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intothree main categories, class I, class II, class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease, chymopapain.CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor, gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma, Kaposi s sarcoma, but with a lower specificity. | |
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