Anti-Fascin-1 Antibody Clone FSCN1/418

Observed Subcellular, Organelle Specific Staining Data:

Variations in Fascin-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney, cells in the molecular layer in cerebellum, cells in the seminiferous ducts in testis, glandular cells in the breast, glial cells in the caudate nucleus and cerebral cortex, Langerhans in skin and squamous epithelial cells in the tonsil. More moderate antibody staining intensity was present in cells in the glomeruli in kidney, cells in the molecular layer in cerebellum, cells in the seminiferous ducts in testis, glandular cells in the breast, glial cells in the caudate nucleus and cerebral cortex, Langerhans in skin and squamous epithelial cells in the tonsil. Low, but measureable presence of Fascin-1 could be seen indecidual cells in the placenta, germinal center cells in the lymph node and tonsil, hematopoietic cells in the bone marrow, keratinocytes in skin, lymphoid tissue in appendix, neuronal cells in the caudate nucleus, neuropil in cerebral cortex, non-germinal center cells in the tonsil, pneumocytes in lung, squamous epithelial cells in the cervix and uterine, esophagus, oral mucosa and vagina. We were unable to detect Fascin-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.