PDF DatasheetHuman Anti-Myeloperoxidase / MPO Antibody Product Attributes
Myeloperoxidase / MPO Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-MPO antibody staining is expected to be primarily localized to the vesicles and nucleus. There is variability in either the signal strength or the localization of signal in nucleus from cell to cell.
Observed Antibody Staining Data By Tissue Type:
Variations in Myeloperoxidase / MPO antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow. Low, but measureable presence of Myeloperoxidase / MPO could be seen in. We were unable to detect Myeloperoxidase / MPO in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| Myeloperoxidase / MPO General Information | |
|---|---|
| Alternate Names | |
| Myeloperoxidase, MPO | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MPO |
| Entrez Gene ID | 4353 |
| Ensemble Gene ID | ENSG00000005381 |
| RefSeq Protein Accession(s) | NP_000241 |
| RefSeq mRNA Accession(s) | NM_000250, |
| RefSeq Genomic Accession(s) | NG_009629, NC_018928, NC_000017 |
| UniProt ID(s) | P05164 |
| UniGene ID(s) | P05164 |
| HGNC ID(s) | 7218 |
| Cosmic ID(s) | MPO |
| KEGG Gene ID(s) | hsa:4353 |
| PharmGKB ID(s) | PA243 |
| General Description of Myeloperoxidase / MPO. | |
| Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. The 150-kDa MPO protein is a cationic homodimer consisting of two covalently bound subunits,each consists of a heavy chain (MW 60kDa) and a light chain (MW 15kDa). MPO plays an important role in inflammatory response by zapping microorganisms and destroying a variety of target materials through catalyzing chloride ion oxidation to hypochlorous acid in the phagocytic cells. On the other hand, MPO causes oxidative modification of low density lipoprotein (LDL) to a high uptake form that is considered to be a key event in the promotion of atherogenesis. For this reason, MPO is believed to participate in the initiation and progression of cardiovascular diseases. At present, MPO is considered to be one of the most promising cardiovascularmarkers and the rise of MPO levels indicates the increased risk of atherosclerosis and coronary heart disease (CHD). MPO level can be increased significantly within two hours for chest pain. Hence, MPO is an early warning marker of myocardial infarction and can be earlier to predict the risk of disease than troponin T, CK-MB and CRP . For patients with chest pain,MPO is then important and clinically significant in the diagnosis of ACS. | |
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