Anti-PCNA Antibody Clone PC10

Observed Subcellular, Organelle Specific Staining Data:

Variations in PCNA antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the appendix, lymphoid tissue in appendix, hematopoietic cells in the bone marrow, glandular cells in the colon, germinal center cells in the lymph node, glandular cells in the small intestine and germinal center cells in the tonsil. More moderate antibody staining intensity was present in glandular cells in the appendix, lymphoid tissue in appendix, hematopoietic cells in the bone marrow, glandular cells in the colon, germinal center cells in the lymph node, glandular cells in the small intestine and germinal center cells in the tonsil. Low, but measureable presence of PCNA could be seen inglandular cells in the adrenal gland, cells in the granular layer in cerebellum, cells in the molecular layer in cerebellum, myocytes in heart muscle, macrophages in lung, pneumocytes in lung, respiratory epithelial cells in the nasopharynx, exocrine glandular cells in the pancreas, glandular cells in the parathyroid gland, trophoblastic cells in the placenta, myocytes in skeletal muscle, Langerhans in skin, smooth muscle cells in the smooth muscle, cells in the red pulp in spleen and glandular cells in the stomach. We were unable to detect PCNA in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.