PDF DatasheetHuman, Mouse, Rat, Horse, Cow, and Canine Anti-TIMP-3 Antibody Product Attributes
Species: Human, Mouse, Rat, Horse, Cow, and Canine
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Polyclonal
Anti-TIMP-3 Antibody Clone:
Clone Host and Isotype: Rabbit IgG
Anti-Human, Mouse, Rat, Horse, Cow, and Canine TIMP-3 Positive Control Sample: Placenta or breast carcinoma
Cellular Localization of Antibody < Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: ImmunogenImmunogen for TIMP3 Ab, is 100% homologous in human, cow, Canine, horse,, 94% homologous in mouse, rat.
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
TIMP-3 Previously Observed Antibody Staining Patterns
| TIMP-3 General Information | |
|---|---|
| Alternate Names | |
| Metalloproteinase inhibitor 3, TIMP3, Tissue Inhibitor of Metalloproteinase 3 | |
| Molecular Weight | |
| 30kDa | |
| Chromosomal Location | |
| 22q12.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TIMP3 |
| Entrez Gene ID | 7078 |
| Ensemble Gene ID | ENSG00000100234 |
| RefSeq Protein Accession(s) | NP_000353 |
| RefSeq mRNA Accession(s) | NM_000362, |
| RefSeq Genomic Accession(s) | NG_029545, NC_000022, NC_018933, NG_009117 |
| UniProt ID(s) | P35625 |
| UniGene ID(s) | P35625 |
| HGNC ID(s) | 11822 |
| Cosmic ID(s) | TIMP3 |
| KEGG Gene ID(s) | hsa:7078 |
| PharmGKB ID(s) | PA36528 |
| General Description of TIMP-3. | |
| TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2,, TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs, the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells, normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia,, in the formation, branching, expansion of epithelial tubes. | |
Limitations and Warranty
enQuire Bio’s TIMP-3 Anti-Human Polyclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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