PDF DatasheetHuman Anti-CD5 (Mantle Cell Lymphoma Marker) Antibody Product Attributes
Species: Human
Tested Applications: WB, IHC.
Clonality: Monoclonal
Anti-CD5 (Mantle Cell Lymphoma Marker) Antibody Clone: CD5/2416
Clone CD5/2416 Host and Isotype: Mouse IgG2b, kappa
Anti-Human CD5 (Mantle Cell Lymphoma Marker) Positive Control Sample: 293T, Ramos, or MOLT-4 Cells. Tonsil or Lymph Node
Cellular Localization of Antibody CD5/2416 Staining: Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant fragment of human CD5 protein (apprx. aa 269-366) (Please call for additional information.)
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
CD5 (Mantle Cell Lymphoma Marker) Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD5 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD5 could be seen in. We were unable to detect CD5 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD5 (Mantle Cell Lymphoma Marker) General Information | |
|---|---|
| Alternate Names | |
| CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5 | |
| Molecular Weight | |
| 67kDa | |
| Chromosomal Location | |
| Ships on blue ice. | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | 921 |
| Entrez Gene ID | CD5 |
| UniProt ID(s) | P06127 |
| UniGene ID(s) | Hs58685 |
| COSMIC ID Link(s) | CD5 |
| KEGG Gene ID(s) | hsa:921 |
| General Description of CD5 (Mantle Cell Lymphoma Marker). | |
| Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes. | |
Limitations and Warranty
enQuire Bio’s product, CD5 (Mantle Cell Lymphoma Marker) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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