PDF DatasheetHuman beta-NGF / Beta-NGF Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant beta-NGF / Beta-NGF based upon sequence from: Human
Host: QP5351 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5351.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 5 ng/mL in the TF-1 cell proliferation assay. The bioactivity acceptance criteria is set at 2 x 10^5 units/mg.
Monomer or Dimer: Dimer
Amino Acid Sequence: MSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human beta-NGF / Beta-NGF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human beta-NGF / Beta-NGF Protein General Information | |
|---|---|
| Alternate Names | |
| beta-NGF, Beta-NGF Protein, HSAN5, Beta-NGF, NGFB | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NGF |
| Entrez Gene ID | 4803 |
| Ensemble Gene ID | ENSG00000134259 |
| RefSeq Protein Accession(s) | NP_002497.2 |
| RefSeq mRNA Accession(s) | NM_002506.2, XM_006710663.3 |
| UniProt ID(s) | P01138 |
| UniGene ID(s) | Hs.2561 |
| HGNC ID(s) | HGNC:7808 |
| COSMIC ID Link(s) | NGF |
| KEGG Gene ID(s) | hsa:4803 |
| PharmGKB ID(s) | PA162397475 |
| General Description of Recombinant Human beta-NGF / Beta-NGF Protein. | |
| Nerve growth factor beta (beta-NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. beta-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. beta-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat beta-NGF proteins are cross-reactive. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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