PDF DatasheetHuman IP-10 / CXCL10 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IP-10 / CXCL10 based upon sequence from Human
Host: QP1011 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP1011.
Bioactivity Data: Human IP-10 / CXCL10 induces Human T cell chemotaxis (significanty different from control at Human IP-10 / CXCL10 concentrations greater than 5 ng/ml)
Monomer or Dimer: Monomer
Amino Acid Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Human IP-10 / CXCL10 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IP-10 / CXCL10 Protein General Information | |
|---|---|
| Alternate Names | |
| C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CXCL10 |
| Entrez Gene ID | 3627 |
| Ensemble Gene ID | ENSG00000169245 |
| RefSeq Protein Accession(s) | NP_001556.2 |
| RefSeq mRNA Accession(s) | NM_001565.3 |
| UniProt ID(s) | P02778 |
| UniGene ID(s) | Hs.632586 |
| HGNC ID(s) | HGNC:10637 |
| COSMIC ID Link(s) | CXCL10 |
| KEGG Gene ID(s) | hsa:3627 |
| PharmGKB ID(s) | PA35568 |
| General Description of Recombinant Human IP-10 / CXCL10 Protein . | |
| Interferon gamma-induced protein 10 (IP-10), or CXCL10, is a chemokine secreted by monocytes, endothelial cells and fibroblasts in response to interferon gamma (IFN-g). IP-10 functions as a chemoattractant for activated T cells, monocytes, dendritic, and natural killer (NK) cells that express the G protein-coupled receptor CXCR3. IP-10 is an important factor in autoimmune diseases such as Hashimoto’s thyroiditis, Graves’ disease, and Type 1 diabetes mellitus. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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