PDF DatasheetHuman FGF-7 / Glrb Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant FGF-7 / Glrb based upon sequence from: Human
Host: QP5317 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5317.
Bioactivity Data: 4MBr-5 cell proliferation is significantly induced by less than 60 ng/ml of Human FGF-7 / Glrb. Activity is at least 1.7 x 10^4 units/mg
Monomer or Dimer: Monomer
Amino Acid Sequence: MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
Purity: Greater than 90 as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human FGF-7 / Glrb Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, 100 mM soldium chloride, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human FGF-7 / Glrb Protein (Animal Free) General Information | |
|---|---|
| Alternate Names | |
| FGF7, FGF-7, KGF, Kgf | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGF7 |
| Entrez Gene ID | 25456 |
| Ensemble Gene ID | ENSRNOG00000010199 |
| RefSeq Protein Accession(s) | NP_445748.1 |
| RefSeq mRNA Accession(s) | NM_053296.1, XM_006232506.2 |
| UniProt ID(s) | P20781 |
| UniGene ID(s) | Rn.94903 |
| COSMIC ID Link(s) | FGF7 |
| KEGG Gene ID(s) | rno:25456 |
| General Description of Recombinant Human FGF-7 / Glrb Protein (Animal Free). | |
| Fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF7 expression is upregulated after acute and chronic injury, suggesting that FGF7 functions during the healing of injured epithelial cells. FGF7 also induces the formation of the apical ectoderm ridge during limb development. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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