PDF DatasheetHuman GDF-15 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GDF-15 based upon sequence from: Human
Host: QP5297 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Immunogen, Protein Standard, Other Cell Biology Applications
Application Notes: Please contact us for application specific information for QP5297.
Bioactivity Data: Untested
Monomer or Dimer: Dimer
Amino Acid Sequence: MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GDF-15 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human GDF-15 Protein General Information | |
|---|---|
| Alternate Names | |
| GDF-15, NAG-1, PDF, PLAB, GDF-15, MIC1, PTGFB, MIC-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GDF15 |
| Entrez Gene ID | 9518 |
| Ensemble Gene ID | ENSG00000130513 |
| RefSeq Protein Accession(s) | NP_004855.2 |
| RefSeq mRNA Accession(s) | NM_004864.3 |
| UniProt ID(s) | Q99988 |
| UniGene ID(s) | Hs.616962 |
| HGNC ID(s) | HGNC:30142 |
| COSMIC ID Link(s) | GDF15 |
| KEGG Gene ID(s) | hsa:9518 |
| PharmGKB ID(s) | PA134866647 |
| General Description of Recombinant Human GDF-15 Protein . | |
| Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-?) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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