PDF DatasheetHuman GDF11 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant GDF11 based upon sequence from: Human
Host: QP5369 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5369.
Bioactivity Data: Alkaline phosphatase activity was demonstrated in ATDC5 cells significantly at concentrations less than 100 ng/ml. Typical ED50 is in the range of 10 ng/ml.
Monomer or Dimer: Dimer
Amino Acid Sequence: NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GDF11 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human GDF11 Protein General Information | |
|---|---|
| Alternate Names | |
| GDF-11, BMP11, BMP-11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GDF11 |
| Entrez Gene ID | 10220 |
| Ensemble Gene ID | ENSG00000135414 |
| RefSeq Protein Accession(s) | NP_005802.1 |
| RefSeq mRNA Accession(s) | NM_005811.4, XM_006719194.3 |
| UniProt ID(s) | O95390 |
| UniGene ID(s) | Hs.600883 |
| HGNC ID(s) | HGNC:4216 |
| COSMIC ID Link(s) | GDF11 |
| KEGG Gene ID(s) | hsa:10220 |
| PharmGKB ID(s) | PA28631 |
| General Description of Recombinant Human GDF11 Protein . | |
| Growth differentiation factor 11 (GDF-11), also known as bone morphogenic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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