PDF DatasheetHuman HBEGF / DTR Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant HBEGF / DTR based upon sequence from: Human
Host: QP5306 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5306.
Bioactivity Data: 3T3 cell proliferation is significantly induced by less than 1 ng/ml Human HBEGF / DTR, (activity greater than 1.0 x 10^6 units/mg).
Monomer or Dimer: Monomer
Amino Acid Sequence: MDLQEADLDL LRVTLSSKP Q ALATPNKE EH GKRKKKG KGL GKKRDP CLRK YKDFC IHGEC KYVK ELRAPS CIC HPGYHGERCH GLSL
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human HBEGF / DTR Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human HBEGF / DTR Protein (Animal Free) General Information | |
|---|---|
| Alternate Names | |
| HBEGF, DTR Protein, HEGFL, DTSF, DTR, DTS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HBEGF |
| Entrez Gene ID | 1839 |
| Ensemble Gene ID | ENSG00000113070 |
| RefSeq Protein Accession(s) | NP_001936.1 |
| RefSeq mRNA Accession(s) | NM_001945.2 |
| UniProt ID(s) | Q99075 |
| UniGene ID(s) | Hs.592942 |
| HGNC ID(s) | HGNC:3059 |
| COSMIC ID Link(s) | HBEGF |
| KEGG Gene ID(s) | hsa:1839 |
| PharmGKB ID(s) | PA27513 |
| General Description of Recombinant Human HBEGF / DTR Protein (Animal Free). | |
| Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family and is expressed by monocytes and macrophages. HB-EGF is the predominant growth factor involved in epithelialization during wound healing. HB-EGF signals through the receptor tyrosine kinase ErbB2 to maintain adult heart homeostasis, and promotes cardiac valve development through binding in high affinity to the epidermal growth factor receptor (EGFR). HB-EGF binds the the ErbB4 receptor tyrosine kinase to mediate implantation of the human blastocyst. HB-EGF also functions as a potent mitogen for fibroblasts and smooth muscle cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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