PDF DatasheetHuman IHH Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IHH based upon sequence from: Human
Host: QP5309 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5309.
Bioactivity Data: Human IHH induces alkaline phosphatase activity in CCL-226 cells (typical ED50 is ? 10 ug/ml).
Monomer or Dimer: Monomer
Amino Acid Sequence: MIIGPGRVVG SRRRPPRKL V PLAYKQFS PN VPEKTLG ASG RYEGKI ARSS ERFKE LTPNY NPDI IFKDEE NTG ADRLMTQRCK DRLNSLA IS VMNQWPGV K LRVTEGWDE DGHHSEESLH YEGRAVDIT T SDRDRNKY GL LARLAVE AGF DWVYYE SKAH VHCSV KSEHSAAAKT GG
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IHH Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IHH Protein (Animal Free) General Information | |
|---|---|
| Alternate Names | |
| BDA1, HHG2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IHH |
| Entrez Gene ID | 3549 |
| Ensemble Gene ID | ENSG00000163501 |
| RefSeq Protein Accession(s) | NP_002172.2 |
| RefSeq mRNA Accession(s) | NM_002181.3 |
| UniProt ID(s) | Q14623 |
| UniGene ID(s) | Hs.654504 |
| HGNC ID(s) | HGNC:5956 |
| COSMIC ID Link(s) | IHH |
| KEGG Gene ID(s) | hsa:3549 |
| PharmGKB ID(s) | PA29769 |
| General Description of Recombinant Human IHH Protein (Animal Free). | |
| Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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