PDF DatasheetHuman IL-1 alpha / IL1A / IL1F1 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-1 alpha / IL1A / IL1F1 based upon sequence from: Human
Host: QP5298 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5298.
Bioactivity Data: To pass QC, D10S cell proliferation must be significantly induced by less than 50 pg/ml or human IL-1 alpha / IL1A / IL1F1 (or activity must be at least 2.0 x 10^7 units/mg).
Monomer or Dimer: Monomer
Amino Acid Sequence: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-1 alpha / IL1A / IL1F1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL-1 alpha / IL1A / IL1F1 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-1 alpha, IL1A, IL1F1 Protein, IL1, IL1-ALPHA, IL1F1, IL-1A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL1A |
| Entrez Gene ID | 3552 |
| Ensemble Gene ID | ENSG00000115008 |
| RefSeq Protein Accession(s) | NP_000566.3 |
| RefSeq mRNA Accession(s) | NM_000575.4 |
| UniProt ID(s) | P01583 |
| UniGene ID(s) | Hs.1722 |
| HGNC ID(s) | HGNC:5991 |
| COSMIC ID Link(s) | IL1A |
| KEGG Gene ID(s) | hsa:3552 |
| PharmGKB ID(s) | PA29807 |
| General Description of Recombinant Human IL-1 alpha / IL1A / IL1F1 Protein . | |
| Interleukin 1 alpha (IL-1?) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1? signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1? and the independently regulated IL-1? protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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