PDF DatasheetHuman IL10 / Interleukin-10 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL10 / Interleukin-10 based upon sequence from: Human
Host: QP5386 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5386.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 5 ng/mL in the MC/9 cell Proliferation assay. The bioactivity acceptance criteria is set at 2 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL10 / Interleukin-10 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL10 / Interleukin-10 Protein (Animal Free) General Information | |
|---|---|
| Alternate Names | |
| IL10, Interleukin-10, IL10A, IL-10, TGIF, CSIF, GVHDS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL10 |
| Entrez Gene ID | 3586 |
| Ensemble Gene ID | ENSG00000136634 |
| RefSeq Protein Accession(s) | NP_000563.1 |
| RefSeq mRNA Accession(s) | NM_000572.2 |
| UniProt ID(s) | P22301 |
| UniGene ID(s) | Hs.193717 |
| HGNC ID(s) | HGNC:5962 |
| COSMIC ID Link(s) | IL10 |
| KEGG Gene ID(s) | hsa:3586 |
| PharmGKB ID(s) | PA29778 |
| General Description of Recombinant Human IL10 / Interleukin-10 Protein (Animal Free). | |
| Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNg), tumor necrosis factor alpha (TNFa), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. Human IL-10 can act on murine cells, while murine IL-10 is not active on human cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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