PDF DatasheetHuman IL13 / ALRH Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL13 / ALRH based upon sequence from: Human
Host: QP5388 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5388.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 5 ng/mL in the TF-1 cell proliferation assay. The bioactivity acceptance criteria is set at 2 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRQFN
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL13 / ALRH Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium citrate, pH 3.0
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL13 / ALRH Protein General Information | |
|---|---|
| Alternate Names | |
| IL13, ALRH, IL-13, P600 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL13 |
| Entrez Gene ID | 3596 |
| Ensemble Gene ID | ENSG00000169194 |
| RefSeq Protein Accession(s) | NP_002179.2 |
| RefSeq mRNA Accession(s) | NM_002188.2 |
| UniProt ID(s) | P35225 |
| UniGene ID(s) | Hs.845 |
| HGNC ID(s) | HGNC:5973 |
| COSMIC ID Link(s) | IL13 |
| KEGG Gene ID(s) | hsa:3596 |
| PharmGKB ID(s) | PA199 |
| General Description of Recombinant Human IL13 / ALRH Protein. | |
| Interleukin 13 (IL-13) is a cytokine secreted from type 2 T helper (Th2) cells. IL-13 has overlapping functions with interleukin 4 (IL-4), including the induction of immunoglobulin E (IgE) secretion from B cells, and the inhibition of interleukin 1 beta (IL-1?), tumor necrosis factor alpha (TNF?), interleukin 8 (IL-8), and interleukin 6 (IL-6) inflammatory cytokine expression. IL-13 also regulates immune cell inflammation in response to the pathophysiological changes of surrounding non-immune cells. The IL-13 receptor consists of the IL-4Ra and IL-13Ra1 subunits. IL-13 can also bind the IL-13Ra2 receptor with high affinity. IL-13 functions are mediated through the JAK/STAT signaling pathway. Human and mouse IL-13 are cross-reactive. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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