PDF DatasheetHuman Interleukin-21 / IL-21 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Interleukin-21 / IL-21 based upon sequence from: Human
Host: QP5394 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5394.
Bioactivity Data: Measured by mino cell proliferation.
Monomer or Dimer: Monomer
Amino Acid Sequence: MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Interleukin-21 / IL-21 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Interleukin-21 / IL-21 Protein General Information | |
|---|---|
| Alternate Names | |
| Interleukin-21, IL-21 Protein, CVID11, IL-21, Za11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL21 |
| Entrez Gene ID | 59067 |
| Ensemble Gene ID | ENSG00000138684 |
| RefSeq Protein Accession(s) | NP_001193935.1 |
| RefSeq mRNA Accession(s) | NM_001207006.2, NM_021803.3 |
| UniProt ID(s) | Q9HBE4 |
| UniGene ID(s) | Hs.567559 |
| HGNC ID(s) | HGNC:6005 |
| COSMIC ID Link(s) | IL21 |
| KEGG Gene ID(s) | hsa:59067 |
| PharmGKB ID(s) | PA29820 |
| General Description of Recombinant Human Interleukin-21 / IL-21 Protein . | |
| Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.