PDF DatasheetMouse IL17 / IL17A Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL17 / IL17A based upon sequence from Mouse
Host: QP5466 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5466.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 5 ng/mL in the Production of IL-6 by mouse 3T3 cells assay. The bioactivity acceptance criteria is set at 2 x 10^5 units/mg.
Monomer or Dimer: Dimer
Amino Acid Sequence: MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Mouse IL17 / IL17A Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Mouse IL17 / IL17A Protein General Information | |
|---|---|
| Alternate Names | |
| IL17, IL17A, CTLA-8, IL-17A, CTLA8, IL-17, IL17 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL17A |
| Entrez Gene ID | 16171 |
| Ensemble Gene ID | ENSMUSG00000025929 |
| RefSeq Protein Accession(s) | NP_034682.1 |
| RefSeq mRNA Accession(s) | NM_010552.3 |
| UniProt ID(s) | Q62386 |
| UniGene ID(s) | Mm.5419 |
| COSMIC ID Link(s) | IL17A |
| KEGG Gene ID(s) | mmu:16171 |
| General Description of Recombinant Mouse IL17 / IL17A Protein. | |
| Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites. Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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