PDF DatasheetMouse IL21 / Interleukin 21 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL21 / Interleukin 21 based upon sequence from Mouse
Host: QP1484 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP1484.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 10 ng/mL in the Mouse thymocyte proliferation assay. The bioactivity acceptance criteria is set at 1 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Mouse IL21 / Interleukin 21 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 20 mM sodium bicarbonate, pH 8.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Mouse IL21 / Interleukin 21 Protein General Information | |
|---|---|
| Alternate Names | |
| IL21, Interleukin 21, IL-21 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL21 |
| Entrez Gene ID | 60505 |
| Ensemble Gene ID | ENSMUSG00000027718 |
| RefSeq Protein Accession(s) | NP_068554.1 |
| RefSeq mRNA Accession(s) | NM_021782.3 |
| UniProt ID(s) | Q9ES17 |
| UniGene ID(s) | Mm.157689 |
| COSMIC ID Link(s) | IL21 |
| KEGG Gene ID(s) | mmu:60505 |
| General Description of Recombinant Mouse IL21 / Interleukin 21 Protein. | |
| Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with interleukin 4 (IL-4) for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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