PDF DatasheetHuman TIR domain-containing adapter molecule 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TIR domain-containing adapter molecule 1 based upon sequence from: Human
Host: QP10006 protein expressed in Invitro-E.coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TIR domain-containing adapter molecule 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10006.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu712
Amino Acid Sequence: MACTGPSLPS AFDILGAAGQ DKLLYLKHKL KTPRPGCQGQ DLLHAMVLLK LGQETEARIS LEALKADAVA RLVARQWAGV DSTEDPEEPP DVSWAVARLY HLLAEEKLCP ASLRDVAYQE AVRTLSSRDD HRLGELQDEA RNRCGWDIAG DPGSIRTLQS NLGCLPPSSA LPSGTRSLPR PIDGVSDWSQ GCSLRSTGSP ASLASNLEIS QSPTMPFLSL HRSPHGPSKL CDDPQASLVP EPVPGGCQEP EEMSWPPSGE IASPPELPSS PPPGLPEVAP DATSTGLPDT PAAPETSTNY PVECTEGSAG PQSLPLPILE PVKNPCSVKD QTPLQLSVED TTSPNTKPCP PTPTTPETSP PPPPPPPSST PCSAHLTPSS LFPSSLESSS EQKFYNFVIL HARADEHIAL RVREKLEALG VPDGATFCED FQVPGRGELS CLQDAIDHSA FIILLLTSNF DCRLSLHQVN QAMMSNLTRQ GSPDCVIPFL PLESSPAQLS SDTASLLSGL VRLDEHSQIF ARKVANTFKP HRLQARKAMW RKEQDTRALR EQSQHLDGER MQAAALNAAY SAYLQSYLSY QAQMEQLQVA FGSHMSFGTG APYGARMPFG GQVPLGAPPP FPTWPGCPQP PPLHAWQAGT PPPPSPQPAA FPQSLPFPQS PAFPTASPAP PQSPGLQPLI IHHAQMVQLG LNNHMWNQRG SQAPEDKTQE AE
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TIR domain-containing adapter molecule 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TIR domain-containing adapter molecule 1 Protein General Information | |
|---|---|
| Alternate Names | |
| IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TICAM1 |
| Entrez Gene ID | 148022 |
| Ensemble Gene ID | ENSG00000127666 |
| RefSeq Protein Accession(s) | NP_891549.1 |
| RefSeq mRNA Accession(s) | NM_182919.3 |
| UniProt ID(s) | Q8IUC6 |
| UniGene ID(s) | Hs.29344 |
| HGNC ID(s) | HGNC:18348 |
| COSMIC ID Link(s) | TICAM1 |
| KEGG Gene ID(s) | hsa:148022 |
| PharmGKB ID(s) | PA142670812 |
| General Description of Recombinant Human TIR domain-containing adapter molecule 1 Protein. | |
| Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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