PDF DatasheetHuman Progesterone-induced-blocking factor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Progesterone-induced-blocking factor 1 based upon sequence from: Human
Host: QP10012 protein expressed in Invitro-E.coli.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Progesterone-induced-blocking factor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10012.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Thr757
Amino Acid Sequence: MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL AFQQKDASKY QELMKQEMET ILLRQKQLEE TNLQLREKAG DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP EYVSVRFYEL VNPLRKEICE LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE SKKAREEMYE KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR EMYERENRNL REARDNAVAE KERAVMAEKD ALEKHDQLLD RYRELQLSTE SKVTEFLHQS KLKSFESERV QLLQEETARN LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL EKDVSNLNKE KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS ENSLLLTKTE PKHVTENQKS KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS KKQKMKT
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Progesterone-induced-blocking factor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Progesterone-induced-blocking factor 1 Protein General Information | |
|---|---|
| Alternate Names | |
| CEP90; C13orf24; PIBF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PIBF1 |
| Entrez Gene ID | 10464 |
| Ensemble Gene ID | ENSG00000083535 |
| RefSeq Protein Accession(s) | NP_006337.2 |
| RefSeq mRNA Accession(s) | NM_006346.2 |
| UniProt ID(s) | Q8WXW3 |
| UniGene ID(s) | Hs.441926 |
| HGNC ID(s) | HGNC:23352 |
| COSMIC ID Link(s) | PIBF1 |
| KEGG Gene ID(s) | hsa:10464 |
| PharmGKB ID(s) | PA162399421 |
| General Description of Recombinant Human Progesterone-induced-blocking factor 1 Protein. | |
| Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2. Isoform 4: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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