PDF DatasheetHuman PLK1 / PLK-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PLK1 / PLK-1 based upon sequence from: Human
Host: QP10044 protein expressed in Baculovirus.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PLK1 / PLK-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10044.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Met1 – Ser603
Amino Acid Sequence: MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP LPERPREKEE PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL KAS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PLK1 / PLK-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PLK1 / PLK-1 Protein General Information | |
|---|---|
| Alternate Names | |
| PLK1; PLK-1; STPK13; PLK | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLK1 |
| Entrez Gene ID | 5347 |
| Ensemble Gene ID | ENSG00000166851 |
| RefSeq Protein Accession(s) | NP_005021.2 |
| RefSeq mRNA Accession(s) | NM_005030.5 |
| UniProt ID(s) | P53350 |
| UniGene ID(s) | Hs.592049 |
| HGNC ID(s) | HGNC:9077 |
| COSMIC ID Link(s) | PLK1 |
| KEGG Gene ID(s) | hsa:5347 |
| PharmGKB ID(s) | PA33410 |
| General Description of Recombinant Human PLK1 / PLK-1 Protein. | |
| Activated by phosphorylation of Thr-210 by AURKA; phosphorylation by AURKA is enhanced by BORA. Once activated, activity is stimulated by binding target proteins. Binding of target proteins has no effect on the non-activated kinase. Several inhibitors targeting PLKs are currently in development and are under investigation in a growing number of clinical trials, such as BI 2536, an ATP-competitive PLK1 inhibitor or BI 6727, a dihydropteridinone that specifically inhibits the catalytic activity of PLK1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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