PDF DatasheetHuman Cdc42 / Rac Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Cdc42 / Rac based upon sequence from: Human
Host: QP10060 protein expressed in Baculovirus.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Cdc42/Rac, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10060.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Gln293
Amino Acid Sequence: MFGKKKKKIE ISGPSNFEHR VHTGFDAQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGPGHA EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPYY RGSHAAKQNG HVMKMKHGEA YYSEVKPLKS DFARFSADYH SHLDSLSKPS EYSDLKWEYQ RASSSSPLDY SFQFTPSRTA GTSGCSKESL AYSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Cdc42 / Rac Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Cdc42 / Rac Protein General Information | |
|---|---|
| Alternate Names | |
| PAK7; p21 protein (Cdc42/Rac)-activated kinase | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PAK7 |
| Entrez Gene ID | 57144 |
| Ensemble Gene ID | ENSG00000101349 |
| RefSeq Protein Accession(s) | NP_065074.1 |
| RefSeq mRNA Accession(s) | NM_020341.3, NM_177990.2, XM_017027960.1, XM_017027961.1, XM_017027962.1, XM_017027963.1, XM_017027964.1, XM_017027965.1 |
| UniProt ID(s) | Q8TB93 |
| UniGene ID(s) | Hs.32539 |
| HGNC ID(s) | HGNC:15916 |
| COSMIC ID Link(s) | PAK7 |
| KEGG Gene ID(s) | hsa:57144 |
| PharmGKB ID(s) | PA32922 |
| General Description of Recombinant Human Cdc42 / Rac Protein. | |
| Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.