PDF DatasheetHuman Polypyrimidine tract-binding protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Polypyrimidine tract-binding protein 1 based upon sequence from: Human
Isoform: Isoform 3
Host: QP10096 protein expressed in Mammal.
Tag: Flag
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Polypyrimidine tract-binding protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10096.
Bioactivity Data: Untested
Full Length? Full length of Isoform 3
Expression Region: Met1 – Ile557
Amino Acid Sequence: MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGAP GIISASPYAG AGFPPTFAIP QAAGLSVPNV HGALAPLAIP SAAAAAAAAG RIAIPGLAGA GNSVLLVSNL NPERVTPQSL FILFGVYGDV QRVKILFNKK ENALVQMADG NQAQLAMSHL NGHKLHGKPI RITLSKHQNV QLPREGQEDQ GLTKDYGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VSEEDLKVLF SSNGGVVKGF KFFQKDRKMA LIQMGSVEEA VQALIDLHNH DLGENHHLRV SFSKSTI
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Polypyrimidine tract-binding protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Polypyrimidine tract-binding protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| pPTB; PTB3; HNRNP-I; PTB; HNRNPI; PTB-T; PTB2; HNRPI; PTB-1; PTB4 | |
| Molecular Weight | |
| Isoform 3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTBP1 |
| Entrez Gene ID | 5725 |
| Ensemble Gene ID | ENSG00000011304 |
| RefSeq Protein Accession(s) | NP_002810.1 |
| RefSeq mRNA Accession(s) | NM_002819.4, NM_031990.3, NM_031991.3 |
| UniProt ID(s) | P26599 |
| UniGene ID(s) | Hs.172550 |
| HGNC ID(s) | HGNC:9583 |
| COSMIC ID Link(s) | PTBP1 |
| KEGG Gene ID(s) | hsa:5725 |
| PharmGKB ID(s) | PA33934 |
| General Description of Recombinant Human Polypyrimidine tract-binding protein 1 Protein. | |
| Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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