PDF DatasheetMouse Roundabout homolog 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Roundabout homolog 1 based upon sequence from: Mouse
Host: QP10099 protein expressed in Mammal.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Roundabout homolog 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10099.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Tyr880 – Ser1612
Amino Acid Sequence: YRHRKKRNGL TSTYAGIRKV PSFTFTPTVT YQRGGEAVSS GGRPGLLNIS EPATQPWLAD TWPNTGNNHN DCSINCCTAG NGNSDSNLTT YSRPADCIAN YNNQLDNKQT NLMLPESTVY GDVDLSNKIN EMKTFNSPNL KDGRFVNPSG QPTPYATTQL IQANLSNNMN NGAGDSSEKH WKPPGQQKPE VAPIQYNIME QNKLNKDYRA NDTIPPTIPY NQSYDQNTGG SYNSSDRGSS TSGSQGHKKG ARTPKAPKQG GMNWADLLPP PPAHPPPHSN SEEYNMSVDE SYDQEMPCPV PPAPMYLQQD ELQEEEDERG PTPPVRGAAS SPAAVSYSHQ STATLTPSPQ EELQPMLQDC PEDLGHMPHP PDRRRQPVSP PPPPRPISPP HTYGYISGPL VSDMDTDAPE EEEDEADMEV AKMQTRRLLL RGLEQTPASS VGDLESSVTG SMINGWGSAS EEDNISSGRS SVSSSDGSFF TDADFAMS-Q AVAAAAEYAG LKVARRQMQD AAGRRHFHAS QCPRPTSPVS TDSNMSAVVI QKARPAKKQK HQPGHLRREA YADDLPPPPV PPPAIKSPTV QSKAQLEVRP VMVPKLASIE ARTDRSSDRK GGSYKGREAL DGRQVTDLRT NPSDPREAQE QPNDGKGRGT RQPKRDLPPA KTHLGQEDIL PYCRPTFPTS NNPRDPSSSS SMSSRGSGSR QREQANVGRR NMAEMQVLGG FERGDENNEE LEETES
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Roundabout homolog 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Roundabout homolog 1 Protein General Information | |
|---|---|
| Alternate Names | |
| AW742721; AW494633; Gm310; DUTT1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Robo1 |
| Entrez Gene ID | 19876 |
| RefSeq Protein Accession(s) | NP_062286.2 |
| RefSeq mRNA Accession(s) | NM_019413.2 |
| UniProt ID(s) | O89026 |
| UniGene ID(s) | Mm.310772 |
| COSMIC ID Link(s) | Robo1 |
| KEGG Gene ID(s) | mmu:19876 |
| General Description of Recombinant Mouse Roundabout homolog 1 Protein. | |
| Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10433822, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). May be required for lung development (PubMed:11734623). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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