PDF DatasheetRabbit HINT1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant HINT1 based upon sequence from: Rabbit
Host: QP10110 protein expressed in Mammal.
Tag: His-Myc
Protein Construction: A DNA sequence encoding the Oryctolagus cuniculus (Rabbit) HINT1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10110.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Gly126
Amino Acid Sequence: ADEIAKAQVA RPGGDTIFGK IIRKEIPAKI IFEDDQCLAF HDISPQAPTH FLVIPKKHIS QISAAEDADE SLLGHLMIVG KKCAADLGLK KGYRMVVNEG SDGGQSVYHV HLHVLGGRQM NWPPG
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rabbit HINT1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rabbit HINT1 Protein General Information | |
|---|---|
| Alternate Names | |
| HINT; Histidine triad nucleotide-binding protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HINT1 |
| Entrez Gene ID | 100009302 |
| Ensemble Gene ID | ENSOCUG00000006607 |
| RefSeq Protein Accession(s) | NP_001076092.1 |
| RefSeq mRNA Accession(s) | NM_001082623.1 |
| UniProt ID(s) | P80912 |
| UniGene ID(s) | Ocu.3078 |
| COSMIC ID Link(s) | HINT1 |
| KEGG Gene ID(s) | ocu:100009302 |
| General Description of Recombinant Rabbit HINT1 Protein. | |
| Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5’monophosphoramidate (AMP-NH2), adenosine 5’monophosphomorpholidate (AMP-morpholidate) and guanosine 5’monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5′-O-phosphorothioate and guanosine 5′-O-phosphorothioate to the corresponding nucleoside 5′-O-phosphates with concomitant release of hydrogen sulfide. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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