PDF DatasheetHuman Tripartite motif-containing protein 72 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Tripartite motif-containing protein 72 based upon sequence from: Human
Host: QP10131 protein expressed in Mammal.
Tag: Flag
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Tripartite motif-containing protein 72, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10131.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Ser269
Amino Acid Sequence: MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL PAAEAHARLK TQLPQQKLQL QEACMRKEKS VAVLEHQLVE VEETVRQFRG AVGEQLGKMR VFLAALEGSL DREAERVRGE AGVALRRELG SLNSYLEQLR QMEKVLEEVA DKPQTEFLMK YCLVTSRLQK ILAESPPPAR LDIQLPIIS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Tripartite motif-containing protein 72 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Tripartite motif-containing protein 72 Protein General Information | |
|---|---|
| Alternate Names | |
| MG53 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TRIM72 |
| Entrez Gene ID | 493829 |
| Ensemble Gene ID | ENSG00000177238 |
| RefSeq Protein Accession(s) | NP_001008275.2 |
| RefSeq mRNA Accession(s) | NM_001008274.3 |
| UniProt ID(s) | Q6ZMU5 |
| UniGene ID(s) | Hs.661859 |
| HGNC ID(s) | HGNC:32671 |
| COSMIC ID Link(s) | TRIM72 |
| KEGG Gene ID(s) | hsa:493829 |
| PharmGKB ID(s) | PA144596247 |
| General Description of Recombinant Human Tripartite motif-containing protein 72 Protein. | |
| Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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