PDF DatasheetHuman SerpinI1 / Neuroserpin Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant SerpinI1 / Neuroserpin based upon sequence from: Human
Host: QP10160 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human SerpinI1 / Neuroserpin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10160.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2000 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: TGATFPEEAI ADLSVNMYNR LRATGEDENI LFSPLSIALA MGMMELGAQG
STQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ N
GFHVNEEF LQMMKKYFNA AVNHVDFSQN VAVANYINKW VENNTNNLVK DL
VSPRDFD AATYLALINA VYFKGNWKSQ FRPENTRTFS FTKDDESEVQ IPM
MYQQGE FYYGEFSDGS NEAGGIYQVL EIPYEGDEIS MMLVLSRQEV PLAT
LEPLV KAQLVEEWAN SVKKQKVEVY LPRFTVEQEI DLKDVLKALG ITEIF
IKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI SRMAVL
YPQ VIVDHPFFFL IRNRRTGTIL FMGRVMHPET MNTSGHD
STQKEIRHS MGYDSLKNGE EFSFLKEFSN MVTAKESQYV MKIANSLFVQ N
GFHVNEEF LQMMKKYFNA AVNHVDFSQN VAVANYINKW VENNTNNLVK DL
VSPRDFD AATYLALINA VYFKGNWKSQ FRPENTRTFS FTKDDESEVQ IPM
MYQQGE FYYGEFSDGS NEAGGIYQVL EIPYEGDEIS MMLVLSRQEV PLAT
LEPLV KAQLVEEWAN SVKKQKVEVY LPRFTVEQEI DLKDVLKALG ITEIF
IKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI SRMAVL
YPQ VIVDHPFFFL IRNRRTGTIL FMGRVMHPET MNTSGHD
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human SerpinI1 / Neuroserpin Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.5, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SerpinI1 / Neuroserpin Protein General Information | |
|---|---|
| Alternate Names | |
| SerpinI1; Neuroserpin; AI837402; PI12; PI-12; Spi17; Ns | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SERPINI1 |
| Entrez Gene ID | 5274 |
| Ensemble Gene ID | ENSG00000163536 |
| RefSeq Protein Accession(s) | NP_001116224.1 |
| RefSeq mRNA Accession(s) | NM_001122752.1, NM_005025.4, XM_017006618.1 |
| UniProt ID(s) | Q99574 |
| UniGene ID(s) | Hs.478153 |
| HGNC ID(s) | HGNC:8943 |
| COSMIC ID Link(s) | SERPINI1 |
| KEGG Gene ID(s) | hsa:5274 |
| PharmGKB ID(s) | PA35511 |
| General Description of Recombinant Human SerpinI1 / Neuroserpin Protein. | |
| Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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