PDF DatasheetHuman SerpinB2 / PAI-2 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant SerpinB2 / PAI-2 based upon sequence from: Human
Host: QP10161 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human SerpinB2 / PAI-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10161.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biologically active was determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37 °C. Half maximal inhibition against 1.0 ug/ml of single chain tPA was at a concentration of 1.0 ug/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH KITNCILFFG RFSSP
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human SerpinB2 / PAI-2 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1 mM Cysteine, with 5 % Trehalose, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SerpinB2 / PAI-2 Protein General Information | |
|---|---|
| Alternate Names | |
| SerpinB2; PAI-2; HsT1201; PAI-2; PAI2; PLANH2; PAI | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SERPINB2 |
| Entrez Gene ID | 5055 |
| Ensemble Gene ID | ENSG00000197632 |
| RefSeq Protein Accession(s) | NP_001137290.1 |
| RefSeq mRNA Accession(s) | NM_001143818.1, NM_002575.2 |
| UniProt ID(s) | P05120 |
| UniGene ID(s) | Hs.594481 |
| HGNC ID(s) | HGNC:8584 |
| COSMIC ID Link(s) | SERPINB2 |
| KEGG Gene ID(s) | hsa:5055 |
| PharmGKB ID(s) | PA35500 |
| General Description of Recombinant Human SerpinB2 / PAI-2 Protein. | |
| Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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