PDF DatasheetHuman TIMP2 / TIMP-2 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TIMP2 / TIMP-2 based upon sequence from: Human
Host: QP10162 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TIMP2 / TIMP-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10162.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biologically active as determined by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR- NH2.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TIMP2 / TIMP-2 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, with 3 % trehalose, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TIMP2 / TIMP-2 Protein General Information | |
|---|---|
| Alternate Names | |
| TIMP2; TIMP-2; DDC8; CSC-21K | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TIMP2 |
| Entrez Gene ID | 7077 |
| Ensemble Gene ID | ENSG00000035862 |
| RefSeq Protein Accession(s) | NP_003246.1 |
| RefSeq mRNA Accession(s) | NM_003255.4 |
| UniProt ID(s) | P16035 |
| UniGene ID(s) | Hs.633514 |
| HGNC ID(s) | HGNC:11821 |
| KEGG Gene ID(s) | hsa:7077 |
| PharmGKB ID(s) | PA36527 |
| General Description of Recombinant Human TIMP2 / TIMP-2 Protein. | |
| Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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