PDF DatasheetHuman CCL14 / HCC-1 / HCC-3 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CCL14 / HCC-1 / HCC-3 based upon sequence from: Human
Host: QP10199 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human CCL14 / HCC-1 / HCC-3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10199.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 5.0-20 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: TESSSRGPYH PSECCFTYTT YKIPRQRIMD YYETNSQCSK PGIVFITKRG HSVCTNPSDK WVQDYIKDMK EN
Purity: Greater than 96% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human CCL14 / HCC-1 / HCC-3 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CCL14 / HCC-1 / HCC-3 Protein General Information | |
|---|---|
| Alternate Names | |
| CCL14; HCC-1; HCC-3; HCC-3; SCYL2; CC-1; HCC-1; MCIF; HCC-1(1-74); NCC-2; NCC2; CC-3; HCC-1/HCC-3; SCYA14; CKB1; SY14 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL14 |
| Entrez Gene ID | 6358 |
| Ensemble Gene ID | ENSG00000276409 |
| RefSeq Protein Accession(s) | NP_116738.1 |
| RefSeq mRNA Accession(s) | NM_032962.4, NM_032963.3 |
| UniProt ID(s) | Q16627 |
| UniGene ID(s) | Hs.272493 |
| HGNC ID(s) | HGNC:10612 |
| KEGG Gene ID(s) | hsa:6358 |
| PharmGKB ID(s) | PA35545 |
| General Description of Recombinant Human CCL14 / HCC-1 / HCC-3 Protein. | |
| Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.