PDF DatasheetHuman CCL21 / 6Ckine Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CCL21 / 6Ckine based upon sequence from: Human
Host: QP10236 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human CCL21 / 6Ckine, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10236.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human lymphocytes is in a concentration range of 10-100 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human CCL21 / 6Ckine Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CCL21 / 6Ckine Protein General Information | |
|---|---|
| Alternate Names | |
| CCL21; 6Ckine; CKb9; SLC; ECL; 6Ckine; SCYA21; TCA4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL21 |
| Entrez Gene ID | 6366 |
| Ensemble Gene ID | ENSG00000137077 |
| RefSeq Protein Accession(s) | NP_002980.1 |
| RefSeq mRNA Accession(s) | NM_002989.3 |
| UniProt ID(s) | O00585 |
| UniGene ID(s) | Hs.57907 |
| HGNC ID(s) | HGNC:10620 |
| COSMIC ID Link(s) | CCL21 |
| KEGG Gene ID(s) | hsa:6366 |
| PharmGKB ID(s) | PA35552 |
| General Description of Recombinant Human CCL21 / 6Ckine Protein. | |
| Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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