PDF DatasheetHuman CCL22 / MDC Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CCL22 / MDC based upon sequence from: Human
Host: QP10237 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human CCL22 / MDC, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10237.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 10-100 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human CCL22 / MDC Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CCL22 / MDC Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL22 |
| Entrez Gene ID | 6367 |
| Ensemble Gene ID | ENSG00000102962 |
| RefSeq Protein Accession(s) | NP_002981.2 |
| RefSeq mRNA Accession(s) | NM_002990.4, XM_017023531.1 |
| UniProt ID(s) | O00626 |
| UniGene ID(s) | Hs.534347 |
| HGNC ID(s) | HGNC:10621 |
| COSMIC ID Link(s) | CCL22 |
| KEGG Gene ID(s) | hsa:6367 |
| PharmGKB ID(s) | PA35553 |
| General Description of Recombinant Human CCL22 / MDC Protein. | |
| May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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