PDF DatasheetHuman IL16 / Interleukin-16 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL16 / Interleukin-16 based upon sequence from: Human
Host: QP10303 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL16 / Interleukin-16, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10303.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human CD4+ T Lymphocytes is in a concentration range of 1.0-100 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL16 / Interleukin-16 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL16 / Interleukin-16 Protein General Information | |
|---|---|
| Alternate Names | |
| IL16; Interleukin-16; prIL-16; NIL16; LCF; PRIL16 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL16 |
| Entrez Gene ID | 3603 |
| Ensemble Gene ID | ENSG00000172349 |
| RefSeq Protein Accession(s) | NP_001165599.1 |
| RefSeq mRNA Accession(s) | NM_001172128.1, NM_004513.5, NM_172217.3, XM_005254346.4, XM_011521520.2, XM_017022141.1, XM_017022142.1 |
| UniProt ID(s) | Q14005 |
| UniGene ID(s) | Hs.459095 |
| HGNC ID(s) | HGNC:5980 |
| COSMIC ID Link(s) | IL16 |
| KEGG Gene ID(s) | hsa:3603 |
| PharmGKB ID(s) | PA29793 |
| General Description of Recombinant Human IL16 / Interleukin-16 Protein. | |
| Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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