PDF DatasheetHuman Interleukin-21 / IL-21 Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Interleukin-21 / IL-21 Protein based upon sequence from: Human
Host: QP10326 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Interleukin-21 / IL-21 Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10326.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by by a cell proliferation assay using human N1186 T cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Interleukin-21 / IL-21 Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Interleukin-21 / IL-21 Protein Protein General Information | |
|---|---|
| Alternate Names | |
| Interleukin-21; IL-21 Protein; CVID11; IL-21; Za11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL21 |
| Entrez Gene ID | 59067 |
| Ensemble Gene ID | ENSG00000138684 |
| RefSeq Protein Accession(s) | NP_001193935.1 |
| RefSeq mRNA Accession(s) | NM_001207006.2, NM_021803.3 |
| UniProt ID(s) | Q9HBE4 |
| UniGene ID(s) | Hs.567559 |
| HGNC ID(s) | HGNC:6005 |
| COSMIC ID Link(s) | IL21 |
| KEGG Gene ID(s) | hsa:59067 |
| PharmGKB ID(s) | PA29820 |
| General Description of Recombinant Human Interleukin-21 / IL-21 Protein Protein. | |
| Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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