PDF DatasheetHuman TNFRSF12A / FN14 / TWEAKR Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TNFRSF12A / FN14 / TWEAKR based upon sequence from: Human
Host: QP10331 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFRSF12A / FN14 / TWEAKR, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10331.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of > 3.3 × 104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFRSF12A / FN14 / TWEAKR Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFRSF12A / FN14 / TWEAKR Protein General Information | |
|---|---|
| Alternate Names | |
| TNFRSF12A; FN14; TWEAKR; FN14; TWEAKR; CD266 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF12A |
| Entrez Gene ID | 51330 |
| Ensemble Gene ID | ENSG00000006327 |
| RefSeq Protein Accession(s) | NP_057723.1 |
| RefSeq mRNA Accession(s) | NM_016639.2 |
| UniProt ID(s) | Q9NP84 |
| HGNC ID(s) | HGNC:18152 |
| COSMIC ID Link(s) | TNFRSF12A |
| KEGG Gene ID(s) | hsa:51330 |
| PharmGKB ID(s) | PA134976874 |
| General Description of Recombinant Human TNFRSF12A / FN14 / TWEAKR Protein. | |
| Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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