PDF DatasheetHuman IL36G / IL1F9 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL36G / IL1F9 based upon sequence from: Human
Host: QP10341 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL36G / IL1F9, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10341.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36gamma at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL36G / IL1F9 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL36G / IL1F9 Protein General Information | |
|---|---|
| Alternate Names | |
| IL36G; IL1F9; IL-1RP2; IL-1H1; IL1H1; IL1E; IL1F9; IL1RP2; IL-1F9 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL36G |
| Entrez Gene ID | 56300 |
| Ensemble Gene ID | ENSG00000136688 |
| RefSeq Protein Accession(s) | NP_001265497.1 |
| RefSeq mRNA Accession(s) | NM_001278568.1, NM_019618.3 |
| UniProt ID(s) | Q9NZH8 |
| UniGene ID(s) | Hs.211238 |
| HGNC ID(s) | HGNC:15741 |
| COSMIC ID Link(s) | IL36G |
| KEGG Gene ID(s) | hsa:56300 |
| PharmGKB ID(s) | PA38395 |
| General Description of Recombinant Human IL36G / IL1F9 Protein. | |
| Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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