PDF DatasheetHuman Plasminogen Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Plasminogen based upon sequence from: Human
Host: QP10364 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Plasminogen, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10364.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Plasminogen Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 20 mM NaAc, pH 5.5, 4 % mannitol, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Plasminogen Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLG |
| Entrez Gene ID | 5340 |
| Ensemble Gene ID | ENSG00000122194 |
| RefSeq Protein Accession(s) | NP_000292.1 |
| RefSeq mRNA Accession(s) | NM_000301.3 |
| UniProt ID(s) | P00747 |
| HGNC ID(s) | HGNC:9071 |
| COSMIC ID Link(s) | PLG |
| KEGG Gene ID(s) | hsa:5340 |
| PharmGKB ID(s) | PA33405 |
| General Description of Recombinant Human Plasminogen Protein. | |
| Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. ; Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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