PDF DatasheetHuman TRAIL R2 / CD262 / TNFRSF10B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TRAIL R2 / CD262 / TNFRSF10B based upon sequence from: Human
Host: QP10367 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TRAIL R2 / CD262 / TNFRSF10B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10367.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. rHusTRAIL-R2 reduced the production of LPS- induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TRAIL R2 / CD262 / TNFRSF10B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein General Information | |
|---|---|
| Alternate Names | |
| TRAIL R2; CD262; TNFRSF10B; TRICKB; TRAIL-R2; CD262; TRAILR2; KILLER; KILLER/DR5; TRICK2A; TRICK2B; ZTNFR9; DR5; TRICK2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF10B |
| Entrez Gene ID | 8795 |
| Ensemble Gene ID | ENSG00000120889 |
| RefSeq Protein Accession(s) | NP_003833.4 |
| RefSeq mRNA Accession(s) | NM_003842.4, NM_147187.2 |
| UniProt ID(s) | O14763 |
| HGNC ID(s) | HGNC:11905 |
| COSMIC ID Link(s) | TNFRSF10B |
| KEGG Gene ID(s) | hsa:8795 |
| PharmGKB ID(s) | PA36598 |
| General Description of Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein. | |
| Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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