PDF DatasheetHuman FAS / CD95 / APO-1 / TNFRSF6 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant FAS / CD95 / APO-1 / TNFRSF6 based upon sequence from: Human
Host: QP10369 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human FAS / CD95 / APO-1 / TNFRSF6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10369.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10-15 ug/ml in the presence of 2 ng/ml of rHuFas Ligand.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human FAS / CD95 / APO-1 / TNFRSF6 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human FAS / CD95 / APO-1 / TNFRSF6 Protein General Information | |
|---|---|
| Alternate Names | |
| FAS; CD95; APO-1; TNFRSF6; CD95; FASTM; APO-1; ALPS1A; APT1; FAS1; TNFRSF6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FAS |
| Entrez Gene ID | 355 |
| Ensemble Gene ID | ENSG00000026103 |
| RefSeq Protein Accession(s) | NP_000034.1 |
| RefSeq mRNA Accession(s) | NM_000043.5, NM_001320619.1, NM_152871.3, NM_152872.3 |
| UniProt ID(s) | P25445 |
| UniGene ID(s) | Hs.244139 |
| HGNC ID(s) | HGNC:11920 |
| COSMIC ID Link(s) | FAS |
| KEGG Gene ID(s) | hsa:355 |
| PharmGKB ID(s) | PA36613 |
| General Description of Recombinant Human FAS / CD95 / APO-1 / TNFRSF6 Protein. | |
| Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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