PDF DatasheetHuman TNFRSF11A Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TNFRSF11A based upon sequence from: Human
Host: QP10370 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFRSF11A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10370.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KCTTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVCDTGKAL VAVVAGNSTT PRRCACTAGY HWSQDCECCR RNTECAPGLG AQHPLQLNKD TVCKPCLAGY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFRSF11A Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFRSF11A Protein General Information | |
|---|---|
| Alternate Names | |
| TNFRSF11A; OFE; FEO; TRANCER; OSTS; PDB2; CD265; LOH18CR1; ODFR; OPTB7; RANK | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF11A |
| Entrez Gene ID | 8792 |
| Ensemble Gene ID | ENSG00000141655 |
| RefSeq Protein Accession(s) | NP_001257878.1 |
| RefSeq mRNA Accession(s) | NM_001270949.1, NM_001270950.1, NM_001270951.1, NM_001278268.1, NM_003839.3 |
| UniProt ID(s) | Q9Y6Q6 |
| UniGene ID(s) | Hs.204044 |
| HGNC ID(s) | HGNC:11908 |
| COSMIC ID Link(s) | TNFRSF11A |
| KEGG Gene ID(s) | hsa:8792 |
| PharmGKB ID(s) | PA36601 |
| General Description of Recombinant Human TNFRSF11A Protein. | |
| Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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