PDF DatasheetHuman HVEM / TNFRSF14 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant HVEM / TNFRSF14 based upon sequence from: Human
Host: QP10371 protein expressed in Yeast.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human HVEM / TNFRSF14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10371.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biologically active as determined by its ability to inhibit TNF-beta -mediated cytotoxicity using murine L929 cells.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKCSWL VTKAGAGTSS SHWVEPKSSD KTHTCPPCPA PEFEGAPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPTP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human HVEM / TNFRSF14 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH7.4, with 3 % Trehalose, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HVEM / TNFRSF14 Protein General Information | |
|---|---|
| Alternate Names | |
| HVEM; TNFRSF14; CD270; HVEA; ATAR; HVEM; LIGHTR; TR2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFRSF14 |
| Entrez Gene ID | 8764 |
| Ensemble Gene ID | ENSG00000157873 |
| RefSeq Protein Accession(s) | NP_003811.2 |
| RefSeq mRNA Accession(s) | NM_003820.3, XM_017002720.1 |
| UniProt ID(s) | Q92956 |
| HGNC ID(s) | HGNC:11912 |
| COSMIC ID Link(s) | TNFRSF14 |
| KEGG Gene ID(s) | hsa:8764 |
| PharmGKB ID(s) | PA36605 |
| General Description of Recombinant Human HVEM / TNFRSF14 Protein. | |
| Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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