PDF DatasheetHuman TNFSF18 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant TNFSF18 based upon sequence from: Human
Host: QP10373 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFSF18, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10373.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFSF18 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TNFSF18 Protein General Information | |
|---|---|
| Alternate Names | |
| TL6; GITRL; AITRL; TNLG2A; hGITRL; Tumor necrosis factor ligand superfamily member | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNFSF18 |
| Entrez Gene ID | 8995 |
| Ensemble Gene ID | ENSG00000120337 |
| RefSeq Protein Accession(s) | NP_005083.2 |
| RefSeq mRNA Accession(s) | NM_005092.3 |
| UniProt ID(s) | Q9UNG2 |
| HGNC ID(s) | HGNC:11932 |
| COSMIC ID Link(s) | TNFSF18 |
| KEGG Gene ID(s) | hsa:8995 |
| PharmGKB ID(s) | PA36624 |
| General Description of Recombinant Human TNFSF18 Protein. | |
| Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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