PDF DatasheetHuman Fibroblast growth factor 23 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Fibroblast growth factor 23 based upon sequence from: Human
Host: QP10385 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Fibroblast growth factor 23, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10385.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ug/ml, corresponding to a specific activity of > 2.0 × 103 IU/mg in the presence of 0.3 ug/ml of rMuKlotho and 10 ug/ml of heparin.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: (M)YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Fibroblast growth factor 23 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Fibroblast growth factor 23 Protein General Information | |
|---|---|
| Alternate Names | |
| HPDR2; PHPTC; ADHR; FGFN; HYPF | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FGF23 |
| Entrez Gene ID | 8074 |
| Ensemble Gene ID | ENSG00000118972 |
| RefSeq Protein Accession(s) | NP_065689.1 |
| RefSeq mRNA Accession(s) | NM_020638.2 |
| UniProt ID(s) | Q9GZV9 |
| HGNC ID(s) | HGNC:3680 |
| COSMIC ID Link(s) | FGF23 |
| KEGG Gene ID(s) | hsa:8074 |
| PharmGKB ID(s) | PA28119 |
| General Description of Recombinant Human Fibroblast growth factor 23 Protein. | |
| Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.