PDF DatasheetHuman HBEGF / DTR Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant HBEGF / DTR Protein based upon sequence from: Human
Host: QP10400 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human HBEGF / DTR Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10400.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human HBEGF / DTR Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered 20 mM PBS, pH 7.4, 130 mM NaCl, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human HBEGF / DTR Protein Protein General Information | |
|---|---|
| Alternate Names | |
| HBEGF; DTR Protein; HEGFL; DTSF; DTR; DTS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HBEGF |
| Entrez Gene ID | 1839 |
| Ensemble Gene ID | ENSG00000113070 |
| RefSeq Protein Accession(s) | NP_001936.1 |
| RefSeq mRNA Accession(s) | NM_001945.2 |
| UniProt ID(s) | Q99075 |
| UniGene ID(s) | Hs.592942 |
| HGNC ID(s) | HGNC:3059 |
| COSMIC ID Link(s) | HBEGF |
| KEGG Gene ID(s) | hsa:1839 |
| PharmGKB ID(s) | PA27513 |
| General Description of Recombinant Human HBEGF / DTR Protein Protein. | |
| Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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