PDF DatasheetHuman IL-29 / Interleukin-29 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-29 / Interleukin-29 based upon sequence from: Human
Host: QP10410 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-29 / Interleukin-29, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10410.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5 ng/ml, corresponding to a specific activity of > 2.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-29 / Interleukin-29 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-29 / Interleukin-29 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-29; Interleukin-29; IL-29; IL29 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IFNL1 |
| Entrez Gene ID | 282618 |
| Ensemble Gene ID | ENSG00000182393 |
| RefSeq Protein Accession(s) | NP_742152.1 |
| RefSeq mRNA Accession(s) | NM_172140.1 |
| UniProt ID(s) | Q8IU54 |
| UniGene ID(s) | Hs.406745 |
| HGNC ID(s) | HGNC:18363 |
| KEGG Gene ID(s) | hsa:282618 |
| PharmGKB ID(s) | PA134899000 |
| General Description of Recombinant Human IL-29 / Interleukin-29 Protein. | |
| Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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