PDF DatasheetHuman MANF / ARMET Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant MANF / ARMET based upon sequence from: Human
Host: QP10418 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human MANF / ARMET, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10418.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 ug/ml, corresponding to a specific activity of > 50 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human MANF / ARMET Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MANF / ARMET Protein General Information | |
|---|---|
| Alternate Names | |
| MANF; ARMET; 3230402M22Rik; AA407711; AA408789; AA673178; Armet; D18Mgi17; D17914 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MANF |
| Entrez Gene ID | 7873 |
| Ensemble Gene ID | ENSG00000145050 |
| RefSeq Protein Accession(s) | NP_006001.4 |
| RefSeq mRNA Accession(s) | NM_006010.5 |
| UniProt ID(s) | P55145 |
| HGNC ID(s) | HGNC:15461 |
| COSMIC ID Link(s) | MANF |
| KEGG Gene ID(s) | hsa:7873 |
| PharmGKB ID(s) | PA24993 |
| General Description of Recombinant Human MANF / ARMET Protein. | |
| Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.